Distribution and Suspected Causes of Methemoglobinemia at an Academic Medical Center

Supplementary file 1: Data for methemoglobin concentrations in whole blood specimens performed at the University of Iowa Hospitals and Clinics from May 1, 2009 to June 22, 2023. The data elements for the “All Values” tab (which contains all methemoglobin values in the above timeframe) include: deidentified patient number, legal sex in the electronic medical record, patient age in years at time of methemoglobin measurement (greater than 89 years expressed as ">89"), location type (outpatient or inpatient) for where methemoglobin measurement was made, quantitative methemoglobin value (%), methemoglobin category (0.0-3.0%, 3.1-4.9%, 5.0-9.9%, and 10+%), and pediatric/adult at time of testing (pediatric defined as < 18 years old). The data elements for the “Episodes with MetHb >=3.1%” field (which contains only those episodes of care with a methemoglobin concentrations of 3.1% or higher) include: deidentified patient number, legal sex in the electronic medical record, patient age in years at time of methemoglobin measurement (greater than 89 years expressed as ">89"), location type (outpatient or inpatient) for where methemoglobin measurement was made, methemoglobin cause category from chart review, highest quantitative methemoglobin value (%) during episode of care, methemoglobin category (0.0-3.0%, 3.1-4.9%, 5.0-9.9%, and 10+%), pediatric/adult (pediatric defined as < 18 years old), asymptomatic during episode (yes/no), cardiovascular symptoms during episode (yes/no), cough during episode (yes/no), cyanosis during episode (yes/no), death during episode of care (yes/no), dizziness and/or loss of balance during episode (yes/no), edema during episode (yes/no), fatigue during episode (yes/no), gastrointestinal pain during episode (yes/no), nausea/vomiting during episode (yes/no), respiratory difficulties during episode (yes/no).

Supplementary file 2: Data for methemoglobin concentrations in whole blood specimens performed at the University of Iowa Hospitals and Clinics from January 1, 1996 to April 30, 2009. The data elements for the “All Values” tab (which contains all methemoglobin values in the above timeframe) are the same as the “All Values” tab in Supplemental file 1. The data elements for the “Episodes with MetHb >=10.0%” field contain only those episodes of care with a methemoglobin concentrations of 10.0% or higher. Data elements are the same as those in the “Episodes with MetHb >=3.1%” tab in Supplemental file 1.

补充文件1：收录了爱荷华大学医院及诊所自2009年5月1日至2023年6月22日期间进行的全血标本中高铁血红蛋白浓度数据的资料。该数据集“所有值”标签下的数据元素包括：去标识化患者编号、电子病历中的法定性别、在高铁血红蛋白测量时的患者年龄（大于89岁者表示为“>89”）、进行高铁血红蛋白测量的地点类型（门诊或住院）、定量高铁血红蛋白值（百分比）、高铁血红蛋白分类（0.0-3.0%、3.1-4.9%、5.0-9.9%及10%以上）、测试时的儿童/成人（儿童定义为<18岁）。“MetHb >=3.1%的病例”字段的数据元素（仅包含那些高铁血红蛋白浓度达到或超过3.1%的护理病例）包括：去标识化患者编号、电子病历中的法定性别、在高铁血红蛋白测量时的患者年龄（大于89岁者表示为“>89”）、进行高铁血红蛋白测量的地点类型（门诊或住院）、由病历审查确定的高铁血红蛋白原因分类、护理期间最高的定量高铁血红蛋白值（百分比）、高铁血红蛋白分类（0.0-3.0%、3.1-4.9%、5.0-9.9%及10%以上）、儿童/成人（儿童定义为<18岁）、护理期间无症状（是/否）、护理期间心血管症状（是/否）、咳嗽（是/否）、发绀（是/否）、护理期间死亡（是/否）、护理期间头晕和/或平衡失调（是/否）、护理期间水肿（是/否）、护理期间疲劳（是/否）、护理期间胃肠道疼痛（是/否）、护理期间恶心/呕吐（是/否）、护理期间呼吸困难（是/否）。

补充文件2：收录了爱荷华大学医院及诊所自1996年1月1日至2009年4月30日期间进行的全血标本中高铁血红蛋白浓度数据的资料。该数据集“所有值”标签下的数据元素与补充文件1中的“所有值”标签相同。‘MetHb >=10.0%的病例’字段的数据元素仅包含那些高铁血红蛋白浓度达到或超过10.0%的护理病例。数据元素与补充文件1中“MetHb >=3.1%的病例”标签下的数据元素相同。