Detection of CTX-M-27 b-lactamases on two distinct plasmid types in ST38 Escherichia coli from several US states, Dec 28 '20

Infections caused by extended-spectrum B-lactamase (ESBL)-producing Escherichia coli are a significant cause of morbidity and healthcare costs. Globally, the prevailing clonal type is ST131. In the United States (US), ST131 is commonly associated with the B-lactamase blaCTX-M-15, whereas blaCTX-M-14 and blaCTX-M-27 are prevalent in other regions. We identified ST38 ESBL-producing E. coli from different regions in the US. This strain is frequently associated with blaCTX-M-27 embedded on two distinct plasmid types, suggesting the potential emergence of new ESBL lineages.