Mus musculus macrophage transcriptome. Mus musculus breed:Balb/c

Study Goals: To understand the impact of macrophage retention of exosomes on macrophage gene expression and function. Additionally, we also wanted to understand the effect of TLR3 stimulation of HEY cells on exosome mediated macrophage functionsRelevance: Exosomes have a multitude of effects in immunomodulation and cancer cells secrete exosomes that alter the fate of cancer progression. In this study we seek to: 1) understand the effect of TLR stimulation on local cells producing exosomes2) understand the impact of cancer secreted exosomes on cancer progression.