Mice lung microbiomes' variable responses to dust exposure

Inhalation of dust is significant and relevant to health effects. As pollution and climate change worsen in dryland regions, wind currents entrain loose sediment and dust. This potentially disperses toxic geochemical and microbial burdens throughout the region. When inhaled environmental dust and host-associated microbiomes mingle, they pose exposure risks to host respiratory health. The Salton Sea, California’s largest lake, is shrinking thus exposing nearby communities to playa dust. Therefore, we analyze the effect of Salton Sea dust exposure in murine models to relate lung microbial communities and respiratory health. We used an environmental chamber to expose mice to dust filtrate or ambient air and examined the effects of those exposures on lung microbiomes. We found that lung microbial composition varied by dust exposure. Furthermore, dust elicited neutrophil recruitment and immune responses more than mice exposed to ambient air. Sources of dust differentially affected the compos..., , # Mice lung microbiomes' variable responses to dust exposure

Dataset DOI: [10.5061/dryad.95x69p8xh](10.5061/dryad.95x69p8xh)

## Description of the data and file structure

These data are metadata related to mouse lung sequences from targeted amplicon sequencing of the marker gene 16S V3-V4 region.

The file WIPD.bac.dat.meta_-_WIPD.bac.dat.meta.csv lists all ASVs and the **complete list of taxa in each sample**

WIPD.bac.dat.meta has 26 column headings. Below is a list of column headers, including information about the meaning of the data in each column of the dataset. PD stands for Palm Desert, and Wi stands for Wister, which are two locations where dust was collected.

* SampleID = which is the name identifying the sample
* ASV_ID = which is the ASV (i.e., exact sequence variant) Identification code
* Kingdom = Kingdom
* Phylum = Phylum
* Class = Class
* Order = Order
* Family = Family
* Genus = Genus
* Species = Species
* Count = the number of reads that ASV has in that particular ...,