DNA damage response-related parameters and associated Wilcoxon rank-sum tests in PBMCs from healthy volunteers and OC patients, sensitive or resistant to platinum therapy.

1HV, Healthy volunteers
2PS, Platinum-sensitive patients
3PR, Platinum-resistant patients
4PBMCs that are defined as having more than 5 foci per cell, expressed as a fraction of 100
5Olive Tail Moment (OTM) values, arbitrary units
6AUC values, expressed as (% of γH2AX positive staining cells) x (carboplatin dose)
7AUC values (expressed as OTM x carboplatin dose)
8t1/2 for γH2AX foci removal, in h
9t1/2 values for carboplatin-induced damage repair, in h
10apoptosis rates expressed as doses of carboplatin inducing apoptosis (as defined in the Materials and Methods section)
11AUC values, expressed as (% of pan-nuclear staining cells) x (carboplatin dose)
12Wilcoxon rank-sum tests
DNA damage response-related parameters and associated Wilcoxon rank-sum tests in PBMCs from healthy volunteers and OC patients, sensitive or resistant to platinum therapy.