Characterization of three Epithelial Ovarian Cancer cell lines resistant to cisplatin (mRNA).

Epithelial ovarian cancer (EOC) represents the gynecologic cancer with the highest mortality rate. Despite a high initial response to chemotherapy, the majority of patients with advanced EOC relapses and subsequently develops chemoresistance that results in treatment failure and death of the patient. AIM: we have generated an isogenic model of PT-resistance in a panel of 3 EOC cell lines. Gene Expression Profile (GEP) was used to identify new molecular pathawy that regulate chemoresistance. GEP experiments were performed in 3 Epithelian Ovarian Cancer cell lines Platinum-resistant vs their parental, with Agilent platform. Bioinformatics analyses were performed by Gene Springs