Localization of gadolinium in atherosclerotic human carotid arteries (thromboendarterectomy specimens) following GBCA-based MRI
收藏ESRF Portal2028-01-01 更新2026-04-23 收录
下载链接：
https://doi.esrf.fr/10.15151/ESRF-ES-2104241750
下载链接
链接失效反馈官方服务：
资源简介：
Gadolinium (Gd)-based contrast agents (GBCA) are applied intravenously (i.v.) to patients to enhance the diagnostic value of magnetic resonance imaging (MRI). Gd-based MRI is a cornerstone of non-invasive imaging in the context of stroke. Late Gd enhancement (LGE) in carotid plaques has previously been associated with rupture-prone plaque phenotypes, but reasons for LGE are largely unknown. Recent findings indicate that glycosaminoglycans (GAGs) might act as initiator of Gd-retention. Therefore, we plan to use synchrotron-based micro-X-ray fluorescence analysis (SR-μXRF) for imaging Gd distribution in tissue sections of human atherosclerotic plaques, and to correlate the Gd distribution with histological markers. Our results will contribute to elucidate the mechanisms of Gd accumulation in atherosclerotic tissues, might influence the safety assessment of GBCA and also might lead to a reassessment of diagnostic criteria for GBCA-enhanced MRI of human carotid atherosclerosis.
提供机构：
Technical University of Berlin, Institute for Optics and Atomare Physics IOAP, Hardenbergstrasse 36, 10623 Berlin, Germany; Technical University of Berlin, Institute for Optics and Atomare Physics IOAP, Hardenbergstrasse 36, 10623, Berlin, GERMANY; Charite - Universitaetsmedizin Berlin, Clinic for Cardiology CCM, Charitéplatz 1, 10117, Berlin, DE; Xploraytion GmbH, Basic Research, Invalidenstrasse 34, 10115 Berlin, Germany; Technische Universitat Berlin, Institut fuer Atomare & Analytische Physik, Sekr PN3-2 Strasse des 17 Juni 135, 10623 , Berlin, DE
创建时间：
2028-01-01
