Genome-wide analysis of human endometria

Intrauterine adhesions (IUA) are the most common reason of uterine infertility, which is characterized by partial or complete closure of uterine cavity and endometrial progressive fibrosis. This disease is often secondary to uterine curettage or other intrauterine surgery. The clinical manifestations include hypomenorrhea even amenorrhea, infertility or recurrent spontaneous abortion. In this work, endometria samples were collected from IUA and control patients. RNA-seq was performed to identify differences in circRNAs and miRNAs expression. This study may provide further insight in the mechanisms of IUA and function as preventive, predictive and therapeutic measures. Overall design: Endometria samples from 3 IUA patients (Ba) and 3 normal controls (Con)