Transcriptomic Characterization of Local Invasion in Human Bladder Cancer by Single Cell RNA Sequencing. Transcriptomic Characterization of Local Invasion in Human Bladder Cancer by Single Cell RNA Sequencing

Investigating intra-tumor heterogeneity of bladder cancer has been largely based on conventional pathological staging and bulk samples sequencing for analyzed multiple spatially separated regions within one tumor. However, it still lack a comprehensive understanding for this question at single cell resolution. Overall design: Single cell mRNA profiles of seven primary tumor samples and one paracancerous tissue sample from seven patients with bladder cancer were generated by 10X Genomics plartform, without technical replication, and sequenced by NovaSeq 6000 (Illumina)