BIOGRID CURATED DATA FOR PUBLICATION: Global mapping of the yeast genetic interaction network.

Protein-Protein, Genetic, and Chemical Interactions for Tong AH (2004):Global mapping of the yeast genetic interaction network. curated by BioGRID (https://thebiogrid.org); ABSTRACT: A genetic interaction network containing approximately 1000 genes and approximately 4000 interactions was mapped by crossing mutations in 132 different query genes into a set of approximately 4700 viable gene yeast deletion mutants and scoring the double mutant progeny for fitness defects. Network connectivity was predictive of function because interactions often occurred among functionally related genes, and similar patterns of interactions tended to identify components of the same pathway. The genetic network exhibited dense local neighborhoods; therefore, the position of a gene on a partially mapped network is predictive of other genetic interactions. Because digenic interactions are common in yeast, similar networks may underlie the complex genetics associated with inherited phenotypes in other organisms.

蛋白质-蛋白质、遗传以及化学相互作用数据集（Tong AH，2004）：针对酵母遗传相互作用网络的全球映射。由BioGRID（https://thebiogrid.org）进行整理；摘要：通过将132个不同查询基因的突变与约4700个可存活的酵母基因删除突变体组合，并评估双突变后代的功能缺陷，构建了一个包含约1000个基因和约4000个相互作用的遗传相互作用网络。网络的连通性能够预测功能，因为功能相关的基因之间往往存在相互作用，且相似的相互作用模式有助于识别同一路径的组成部分。遗传网络表现出密集的局部邻域；因此，基因在部分映射网络中的位置可以预测其他遗传相互作用。由于酵母中的二基因相互作用较为普遍，类似的网络可能构成了其他生物体中与遗传表型相关的复杂遗传学的潜在基础。