Baseline risk factors for treatment failure in late stage patients.

TT: treatment; E: eflornithine treatment; M: melarsoprol treatment; M-E: combination of melarsoprol and eflornithine; M-N: combination of melarsoprol and nifurtimox. n/N: n = number of patients experiencing treatment failure, N = total number of patients. RR: risk ratio. T−: absence of parasite in CSF; T+: presence of parasites in CSF. NS−: absence of neurological sings, NS+: presence of neurological sings. Age and WBC/µL categories were defined according to Mumba Ngoyi D. et al.[8].