Genome-wide screening and characterization of Actinobacillus pleuropneumoniae and its ciprofloxacin-resistant mutants

Understanding constraints which shape antibiotic resistance is key for predicting and controlling drug resistance. Here, we performed high-throughput laboratory evolution of Actinobacillus pleuropneumoniae and its ciprofloxacin resistance-inducing derivatives.This study aims to explore the mechanism of acquired ciprofloxacin resistance in Actinobacillus pleuropneumoniae. APP strain SC1810 and its ciprofloxacin-resistance mutant