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Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models

NIAID Data Ecosystem2026-03-13 收录

胶质母细胞瘤免疫治疗

肿瘤微环境重编程

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE197762 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2022-09-06

胶质母细胞瘤免疫治疗

免疫检查点

Recently, ‘don’t eat me’-signals like CD47 have emerged as novel innate immune checkpoints, enabling cancer cells to evade clearance by phagocytes such as microglia (MG) or monocyte-derived cells (MdC

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CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment. CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment

胶质母细胞瘤免疫治疗

CD70

We have used our established Glioblastoma cell models and gene expression analyses to characterize gene wild-type and CD70 knockdown GBM cell lines Overall design: We utilized early passage Glioblasto

NIAID Data Ecosystem30

cGAS-agonistic Spherical Nucleic Acids reprogram the glioblastoma immune microenvironment and promote anti-tumor immunity

胶质母细胞瘤免疫治疗

核酸药物递送

Intratumorally delivered STING-agonistic cyclic dinucleotides (CDN) exhibit therapeutic benefit in preclinical glioblastoma (GBM) models, but inadequate bioavailability limits CDN therapy to invasive

NIAID Data Ecosystem20

Additional file 7 of Epigenetic remodeling to improve the efficacy of immunotherapy in human glioblastoma: pre-clinical evidence for development of new immunotherapy approaches

胶质母细胞瘤免疫治疗

表观遗传药物机制

Additional file 7: Table S1: Upstream regulators by guadecitabine in all tumor types; Table S2: Enrichment analysis of Upstream regulators up-regulated in GBM vs MM-BM; Table S3: Enrichment analysis o

NIAID Data Ecosystem40

Gene expression profile of CD8+ T cells in glioblastoma after ex vivo treatment of anti-PD-1 and/or galunisertib.

胶质母细胞瘤免疫治疗

CD8+ T细胞转录组

We aimed to analyze the effects of anti-PD-1 and/or galunisertib on tumor-infiltrating CD8+ T cells in glioblastoma. Anti-CD3 with anti-PD-1 and/or galunisertib was treated to single cell suspension o

NIAID Data Ecosystem30

Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models

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