Fine Mapping and Candidate Gene Analysis of Dravet Syndrome Modifier Loci on Mouse Chromosomes 7 and 8

Fine Mapping of Dravet Syndrome Modifier Loci on Mouse Chromosomes 7 and 8. 

Hawkins2024_Dsm2_Dsm3_Survival.xlsx - Survival data used for mapping are contained in this workbook.

Contents:

Sheet 1: Dsm2 / Chromosome 7 Survival

Column A: age at event (death or censoring)
Columns B-J: event (1=death; 0=censored) by line
Sheet 2: Dsm3 / Chromosome 8 Survival

Column A: age at event (death or censoring)
Columns B-J: event (1=death; 0=censored) by line
Hawkins2024_Dsm2b_SNPs.csv - C57BL/6J v 129S6/SvEvTac SNPs in Dsm2b (see below for column content)
Hawkins2024_Dsm2b_Indels.csv - C57BL/6J v 129S6/SvEvTac Indels in Dsm2b (see below for column content)
Hawkins2024_Dsm3_SNPs.csv -   C57BL/6J v 129S6/SvEvTac SNPs in Dsm3 (see below for column content)
Hawkins2024_Dsm3_Indels.csv - C57BL/6J v 129S6/SvEvTac Indels in Dsm3 (see below for column content)

Column Descriptions for Files 2-5

Column A: Chr - Chromosome
Column B: Start (m39) - Start position in m39 Genome Assembly
Column C: End (m39) - End position in m39 Genome Assembly
Column D: Func - variant class
Column E: Gene - Gene symbol
Column F: Exonic|Biotype - variant type
Column G: Transcript - Trancript ID and variant
Column H: Codon_Change - the alternative codons with the variant base in upper case
Column I: Impact - the impact modifier for the consequence type
Column J: dbSNP - dbSNP ID
Column K: LOF|NMD - ratio of transcripts with loss of function or nonsense mediated decay
Column L: Chr Chromosome
Column M: Start (mm10) - Start position in mm10 Genome Assembly
Column N: End (mm10) - End position in mm10 Genome Assembly
Column O: Ref - Reference base
Column P: Obs - Alternate non-reference allele
Column Q: Otherinfo - zygosity
Column R: isoform - all transcripts