Fine Mapping and Candidate Gene Analysis of Dravet Syndrome Modifier Loci on Mouse Chromosomes 7 and 8

Fine Mapping of Dravet Syndrome Modifier Loci on Mouse Chromosomes 7 and 8. Hawkins2024_Dsm2_Dsm3_Survival.xlsx - Survival data used for mapping are contained in this workbook. Contents: Sheet 1: Dsm2 / Chromosome 7 Survival Column A: age at event (death or censoring) Columns B-J: event (1=death; 0=censored) by line Sheet 2: Dsm3 / Chromosome 8 Survival Column A: age at event (death or censoring) Columns B-J: event (1=death; 0=censored) by line Hawkins2024_Dsm2b_SNPs.csv - C57BL/6J v 129S6/SvEvTac SNPs in Dsm2b (see below for column content) Hawkins2024_Dsm2b_Indels.csv - C57BL/6J v 129S6/SvEvTac Indels in Dsm2b (see below for column content) Hawkins2024_Dsm3_SNPs.csv - C57BL/6J v 129S6/SvEvTac SNPs in Dsm3 (see below for column content) Hawkins2024_Dsm3_Indels.csv - C57BL/6J v 129S6/SvEvTac Indels in Dsm3 (see below for column content) Column Descriptions for Files 2-5 Column A: Chr - Chromosome Column B: Start (m39) - Start position in m39 Genome Assembly Column C: End (m39) - End position in m39 Genome Assembly Column D: Func - variant class Column E: Gene - Gene symbol Column F: Exonic|Biotype - variant type Column G: Transcript - Trancript ID and variant Column H: Codon_Change - the alternative codons with the variant base in upper case Column I: Impact - the impact modifier for the consequence type Column J: dbSNP - dbSNP ID Column K: LOF|NMD - ratio of transcripts with loss of function or nonsense mediated decay Column L: Chr Chromosome Column M: Start (mm10) - Start position in mm10 Genome Assembly Column N: End (mm10) - End position in mm10 Genome Assembly Column O: Ref - Reference base Column P: Obs - Alternate non-reference allele Column Q: Otherinfo - zygosity Column R: isoform - all transcripts