Histone Deacetylase 6‑Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity
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资源简介：
Four crystal structures are presented of histone deacetylase 6 (HDAC6) complexes with para-substituted phenylhydromaxamate inhibitors, including bulky peptoids. These structures provide insight regarding the design of capping groups that confer selectivity for binding to HDAC6, specifically with regard to interactions in a pocket formed by the L1 loop. Capping group interactions may also influence hydroxamate-Zn2+ coordination with monodentate or bidentate geometry.
创建时间：
2018-08-17
