Sex-Associated Gene Database

Many animal species present sex differences. Sex-associated genes (SAGs), which have female-biased or male-biased expression, have major influences on the remarkable sex differences in important traits such as growth, reproduction, disease resistance and behaviors. However, the SAGs resulting in the vast majority of phenotypic sex differences are still unknown. To provide a useful resource for the functional study of SAGs, we manually curated public RNA-seq datasets with paired female and male biological replicates from the same condition and systematically re-analyzed the datasets using standardized methods. We identified 27,793 female-biased SAGs and 64,043 male-biased SAGs from 2,828 samples of 21 species, including human, chimpanzee, macaque, mouse, rat, cow, horse, chicken, zebrafish, seven fly species and five worm species. All these data were cataloged into SAGD, a user-friendly database of SAGs where users can browse SAGs by gene, species, drug, and dataset. In SAGD, the expression, annotation, targeting drugs, homologs, ontology and related RNA-seq datasets of SAGs are provided to help researchers to explore their functions and potential applications in agriculture and human health.

诸多动物物种均存在性别差异。性别相关基因（Sex-associated genes, SAGs）的表达具有雌性偏向或雄性偏向特征，对生长、繁殖、抗病性及行为等重要性状的显著性别差异具有关键调控作用。然而，绝大多数表型性别差异背后的性别相关基因仍未被探明。为给性别相关基因的功能研究提供实用资源，我们手动整理了来自同一实验条件、包含雌雄配对生物学重复样本的公共RNA-seq数据集，并采用标准化方法对其进行系统性重分析。我们从21个物种的2828个样本中鉴定出27793个雌性偏向性性别相关基因与64043个雄性偏向性性别相关基因，涵盖人、黑猩猩、猕猴、小鼠、大鼠、牛、马、鸡、斑马鱼、7种蝇类以及5种蠕虫类。所有数据均被收录至SAGD——一个用户友好的性别相关基因数据库，用户可按基因、物种、药物及数据集维度检索该数据库中的性别相关基因。在SAGD数据库中，我们提供了性别相关基因的表达量、注释信息、靶向药物、同源基因、本体注释及相关RNA-seq数据集，以助力研究人员探索其功能以及在农业与人类健康领域的潜在应用价值。

搜集汇总

背景与挑战

背景概述

SAGD是一个性别相关基因数据库，系统整合了公共转录组数据，包含21个物种的91,836个性别相关基因，这些基因在雌雄个体中表达差异显著，影响形态、生理和行为表型。该数据库基于2,828个样本分析，提供按基因、物种、药物和数据集浏览的功能，以支持性别相关基因的功能研究和应用。