Genome-wide off target detection of Un1Cas12f1 in mouse models
收藏NIAID Data Ecosystem2026-05-01 收录
下载链接：
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA963402
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资源简介：
Hypercompact Cas12f1 were demonstrated with eukaryotic nuclease activity showing great potential as AAV-based gene therapy system. Our present study provided definitive results for developing Cas12f1-based therapy for in vivo diseases treatment with tyrosineamia mouse model. We conducted genome-wide off-target analysis using PEM-seq for gene knockout with Cas12f1. PEM-seq detected no off-target editing events for Cas12f1-mediated gene editing.
创建时间：
2023-04-30
