HNF1B induced three-dimensional genome analysis of patient-derived pancreas neoplasm organoids [RNA-seq]

Three-dimensional (3D) genome structures are organized in a hierarchy of various module layers, including chromosome compartment, topologically associating domain, and enhancer-promoter loop. These modules are important in regulating cell type specific gene expression. Here, we aimed to elucidate how 3D genome organization is related to regulating subtype specific genes in pancreatic neoplasms. 3D genome structure analysis together with epigenomic and expression profiling using patient-derived organoids. HNF1B was overexpressed to identify its role in subtype specific genome modulation. **Please note that raw data are submitted to JGA (Japanese Genotype-phenotype Archive) with JGAS000514 accession number***