The elucidation of the anti-inflammatory mechanism of EMO in rheumatoid arthritis through an integrative approach combining bioinformatics and experimental verification

Emodin (EMO), a natural derivative of the anthraquinone family mainly extracted from rhubarb (Rheum palmatum), has previously been demonstrated to possess superior anti-inflammatory properties from a single target or pathway. In order to explore the underlying mechanism of action of EMO against rheumatoid arthritis (RA), a network pharmacology approach was employed.大黄素（Emodin, EMO）是蒽醌类家族的天然衍生物，主要提取自掌叶大黄（Rheum palmatum）。既往研究已证实，其可通过单一靶点或通路发挥优异的抗炎活性。为探究大黄素对抗类风湿关节炎（rheumatoid arthritis, RA）的潜在作用机制，本研究采用了网络药理学方法。