Genome sequencing of high glucose-treated mouse renal tubular epithelial cells

Transfer RNA-derived fragments (tRFs), a novel class of small noncoding RNA (sncRNA) produced by the cleavage of pre- and mature tRNAs, have been reported to be involved in various diseases. Renal tubulointerstitial fibrosis (TIF) is a common final pathway in diabetic nephropathy (DN) in which hyperglycemia-induced tubular extracellular matrix (ECM) accumulation plays a vital role. This study aimed to detect and investigate the role of tRFs in the accumulation of tubular ECM.