A neonatal case of Sepsis-Like Symptoms by Human Parechovirus Type 5 : first Japanese case and comparison with published HPeV5 and HPeV3 reports

Human Parechovirus (HPeV) is the second most common pathogen, after enteroviruses, causing viral sepsis and meningitis in the neonatal and infancy periods . Specifically, HPeV3 is known to present with fever, rash, and severe irritability in neonates and infants, often requiring intensive care due to sepsis-like symptoms . HPeV5, on the other hand, was previously reported as a cause of gastroenteritis and acute diarrhea , but recently, case reports of sepsis-like syndrome and central nervous system infections have been increasingly observed overseas . We report a case of a neonate who presented with sepsis-like symptoms caused by HPeV5, for which we performed whole-genome sequencing.