Synthesis and in Vitro Screening of New Series of 2,6-Dipeptidyl-anthraquinones: Influence of Side Chain Length on HIV‑1 Nucleocapsid Inhibitors
收藏NIAID Data Ecosystem2026-03-09 收录
下载链接：
https://figshare.com/articles/dataset/Synthesis_and_in_Vitro_Screening_of_New_Series_of_2_6_Dipeptidyl_anthraquinones_Influence_of_Side_Chain_Length_on_HIV_1_Nucleocapsid_Inhibitors/2084533
下载链接
链接失效反馈官方服务：
资源简介：
2,6-Dipeptidyl-anthraquinones are
a promising class of nucleic
acid-binding compounds that act as NC inhibitors in vitro. We designed,
synthesized, and tested new series of 2,6-disubstituted-anthraquinones,
which are able to bind viral nucleic acid substrates of NC. We demonstrate
here that these novel derivatives interact preferentially with noncanonical
structures of TAR and cTAR, stabilize their dynamics, and interfere
with NC chaperone activity.
创建时间：
2016-03-10
