Adult nucleus accumbens single-nucleus RNA-seq dataset for "Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine"

This dataset contains single-nucleus RNA sequencing results from adult rat brain (nucleus accumbens) and serves as the basis for characterization of transcriptional response to repeated cocaine injections (20mg/kg, intraperitoneal injection). The goal of this experiment was to define the transcriptional response to repeated cocaine across distinct cell types in the nucleus accumbens. Single-cell sequencing was carried out with FACS-sorted nuclei isolated from these experiments using the 10X Genomics Chromium single cell sequencing platform.本数据集收录成年大鼠大脑伏隔核（nucleus accumbens）的单细胞核RNA测序（single-nucleus RNA sequencing）结果，可为解析反复可卡因注射（20mg/kg，腹腔注射（intraperitoneal injection））诱导的转录应答提供核心数据支撑。本实验的研究目标为明确伏隔核内不同细胞类型对反复可卡因给药的转录应答特征。本次测序采用10X Genomics Chromium单细胞核测序平台，对本实验中分离得到的、经荧光激活细胞分选（fluorescence-activated cell sorting，FACS）富集的细胞核开展测序工作。