Nasopharyngeal virome analysis of COVID-19 patients during three different waves in Campania Region of Italy.

From December 2019, SARS-CoV-2 infection has spread rapidly, leading to a global pandemic. Little is known about possible relationships between SARS-CoV-2 and other viruses in the respiratory system affecting patient prognosis and outcomes. This study aims to characterize respiratory virome profiles in association with SARS-CoV-2 infection and disease severity, through the analysis in 89 nasopharyngeal swabs collected in a patient’s cohort from the Campania region (Southern Italy).We found coinfections with viral species that belonged to <em>Coronaviridae, Retroviridae</em>, <em>Herpesviridae</em>, <em>Poxviridae</em>, <em>Pneumoviridae</em>, <em>Pandoraviridae,</em> and <em>Anelloviridae </em>families and only in 2% of cases (2/89) we identified respiratory viruses.