High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

ChEBI2015-11-25 更新2026-07-12 收录

疾病靶点发现

功能基因组筛选

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-75189 数据链接链接失效反馈

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资源简介：

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

创建时间：

2015-11-25

PerturBench

单细胞扰动分析

疾病靶点发现

PerturBench是由Altos Labs开发的一个综合框架，旨在标准化细胞扰动分析领域的基准测试。该数据集包含多种扰动模式的数据，覆盖了化学和遗传扰动，以及组合扰动，数据量从数十万到数百万不等。数据集的创建过程涉及对现有数据集的筛选和预处理，以模拟真实世界的挑战。PerturBench主要应用于计算方法预测基因表达的扰动效应，旨在通过高吞吐量和高内容遗传及化学筛选，推动疾病靶点发现的研究。

arXiv2024-08-20 更新1570

DataSheet_1_Proteomic Analyses Identify Therapeutic Targets in Hepatocellular Carcinoma.xlsx

肝细胞蛋白质组学

疾病靶点发现

Hepatocellular carcinoma (HCC) is the fourth cause of cancer-related mortality worldwide. While many targeted therapies have been developed, the majority of HCC tumors do not harbor clinically actiona

NIAID Data Ecosystem50

Data sheet index below 1.

功能基因组筛选

肿瘤代谢

In vitro and in vivo growth screen data, HCC827 cells, Source data for Fig 1. Mini-library CRISPRi screen in HCC827 cells, raw data. The read counts for each sgRNA in all in vitro and in vivo (flank a

Figshare2022-09-22 更新50

Sphingobium chlorophenolicum Confronts the Stresses Associated with Pentachlorophenol and Four Toxic Downstream Metabolites to Utilize a Suboptimal Nutrient Source [Tn-Seq]

微生物降解基因

功能基因组筛选

Pentachlorophenol (PCP) is a highly toxic pesticide that was first introduced in the 1930s. The a-proteobacterium Sphingobium chlorophenolicum, which was isolated from PCP-contaminated sediment, has a

NIAID Data Ecosystem60

YAP1 and PRDM14 converge to regulate cell survival and tumorigenesis

肿瘤发生机制

疾病靶点发现

The transcriptional co-activator YAP1 oncogene is the downstream effector of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. Multiple cancers are dep

NIAID Data Ecosystem50

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

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