Correlations^* and effect estimates (β) ^† between total urinary arsenic (As), DNA methylation and gene expression in Argentina, as well as the influence of haplotype on gene expression.

A. denotes CpG sites that were positively associated with the AS3MT haplotype and B. denotes CpG sites that were inversely associated with the haplotype. *rs and p-value from Spearman correlation. †β and p-value from multivariable regression. ‡Model (the β stated in the table is β1): Gene expression = α+β1× total urinary arsenic (natural ln transformed)+β2× RIN. §Model (the β stated in the table is β1): Gene expression = α+β1×copies of AS3MT haplotype+β2× total urinary arsenic (natural ln transformed)+β3×RIN. ¶Model (the β stated in the table is β1): Gene expression = α+β1×methylation level+β2× total urinary arsenic (natural ln transformed)+β3×RIN.