E-MTAB-5102

NIAID Data Ecosystem2026-05-02 收录

前列腺癌靶向治疗

小分子药物

数据链接：

https://www.omicsdi.org/dataset/atlas-experiments/E-MTAB-5102 数据链接链接失效反馈

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资源简介：

Development of a small molecule for treatment of castration resistant prostate cancer via androgen receptor and IL6/STAT3 pathways

创建时间：

2025-01-23

KRASG12C GDP form in complex with Cpd3

KRASG12C

小分子药物

KRASG12C GDP form in complex with Cpd3 Descriptor: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... Authors: Mathieu, M, Steier, V. Deposit date: 2020-08-14 Release date: 2021-1

Protein Data Bank Japan2024-11-20 更新90

Treatment with the WNT5A-mimicking Peptide Foxy-5 Effectively Reduces the Metastatic Spread of WNT5A-low Prostate Cancer Cells in an Orthotopic Mouse Model

前列腺癌靶向治疗

癌症转移抑制模型

The raw data behind the figures of the published paper

Figshare2017-08-28 更新30

Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor through Virtual Screening.

药物虚拟筛选

前列腺癌靶向治疗

The androgen receptor (AR) is the best studied drug target for the treatment of prostate cancer. While there are a number of drugs that target the AR, they all work through the same mechanism of actio

NIAID Data Ecosystem10

Characterization of RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling

Nrf2信号通路

小分子药物

The activation of the transcription factor NF-E2-related factor 2 (Nrf2) maintains cellular homeostasis in response to oxidative stress by the regulation of multiple cytoprotective genes. Without stre

NIAID Data Ecosystem50

Structure-Based Discovery of Hsp90/HDAC6 Dual Inhibitors Targeting Aggressive Prostate Cancer

前列腺癌靶向治疗

HDAC6-Hsp90双重抑制剂

HDAC6 and Heat Shock Protein 90 (Hsp90) are key regulators within the androgen response pathway, exhibiting a close interplay and mutual interaction patterns that make their combined inhibition a prom

NIAID Data Ecosystem20

E-MTAB-5102

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