Hypoxia inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair

Following myocardial infarction, tissue ischemia leads to activation of hypoxia inducible factors. DeBerge et al. demonstrate that HIF-1a and HIF-2a activation in myeloid cells antagonizes cardiac repair pathways through cleavage of cardioprotective MerTK and suppression of anti-inflammatory mitochondrial metabolism, respectively. Overall design: scRNAseq of 1 deidentified patient with ischemic cardiomypapthy