Manual to Auto-Optimization Platform of Multistep Apixaban Synthesis

A novel
approach has been utilized in a continuous flow
auto-optimizer
for multistep apixaban (APX) synthesis, cutting residence time to
17.2 min and boosting overall yield by 78%. This AI-driven tool bypasses
traditional trial-and-error methods, streamlining reactivity space
navigation and enhancing productivity. It is designed to reduce APX
production costs, improve space-time yield, and facilitate the transition
from batch to continuous manufacturing, addressing critical gaps in
the industry and advancing the field of digital smart workflows.