BIOTECHNOLOGICAL AND STEM CELL–BASED STRATEGIES IN MODERN DENTAL IMPLANTOLOGY FOR SUPERIOR OSSEOINTEGRATION AND MULTITISSUE REGENERATION

Successful dental implantation relies on predictable osseointegration and stable peri-implant tissue regeneration. Autologous stem cell–based therapies have emerged as promising biological enhancers of bone healing and implant integration. To assess the clinical efficacy of peripheral blood– and adipose-derived autologous stem cells in improving osseointegration during dental implantation. Twenty adult patients underwent implant placement in the maxilla and mandible. Autologous stem cells isolated from peripheral blood and adipose tissue were combined with platelet-derived factors and applied to implant surfaces prior to insertion. Clinical, stability, and radiographic outcomes were evaluated over a six-month follow-up period. Stem cell–enriched implants demonstrated accelerated soft tissue healing, increased implant stability, and enhanced bone regeneration. Platelet-derived regulatory factors supported controlled osteogenesis without pathological mineralization.