Structural basis of Jak2 inhibition by the type II inhibtor NVP-BBT594
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Structural basis of Jak2 inhibition by the type II inhibtor NVP-BBT594 Descriptor: 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1H-indole-1-carboxamide, MALONATE ION, Tyrosine-protein kinase JAK2 Authors: Scheufler, C, Tavares, G.A, Manley, P.W, Pissot-Soldermann, C, Kroemer, M. Deposit date: 2011-11-02 Release date: 2012-05-16 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.34 Å) Cite: Modulation of activation-loop phosphorylation by JAK inhibitors is binding mode dependent. Cancer Discov, 2, 2012
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2011-11-02
