Arteriovenous Fistulae in Chronic Kidney Disease and the Heart: Physiological, Histological, and Transcriptomic Characterization of a Novel Rat Model

Arteriovenous fistulae (AVF) are the gold standard for vascular access in those requiring hemodialysis, but may put an extra hemodynamic stress on the cardiovascular system. The complex interactions between the heart, kidney, and AVF remain incompletely understood. In this project, we characterized a novel rat model of 5/6th partial nephrectomy (NX) and AVF.动静脉内瘘（Arteriovenous fistulae, AVF）是需行血液透析患者的血管通路金标准，但会对心血管系统造成额外的血流动力学负荷。心脏、肾脏与动静脉内瘘之间的复杂相互作用仍未得到完全阐明。本研究构建了一种新型的5/6部分肾切除术（NX）联合动静脉内瘘的大鼠模型。