Crystal structure of p53 Y220C mutant in complex with PC-9859

Crystal structure of p53 Y220C mutant in complex with PC-9859 Descriptor: 2-methyl-2-{5-[(3-{4-[(1-methylpiperidin-4-yl)amino]-1-(2,2,2-trifluoroethyl)-1H-indol-2-yl}prop-2-yn-1-yl)amino]pyridin-2-yl}propanenitrile, CHLORIDE ION, Cellular tumor antigen p53, ... Authors: Abendroth, J, Lorimer, D.D, Vu, B, Takana, N. Deposit date: 2024-05-10 Release date: 2024-12-18 Last modified: 2025-01-29 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Discovery of Rezatapopt (PC14586), a First-in-Class, Small-Molecule Reactivator of p53 Y220C Mutant in Development. Acs Med.Chem.Lett., 16, 2025