Expression of miRNAs in mice skin damaged by ultraviolet

Correlated to many vulgaris and intractable skin diseases, photo damage is one of the challenges of skin caused by the ultraviolet. Modulation of miRNAs on gene expression in photo damage have attracted attentions recently. We established a photo damaged Kunming (KM) mouse skin model by UVA irradiation of 89.88 J/cm^2 in total. The skin tissues of the back of the mice were harvested, and the expression of miRNA was assayed. Difference in expression of miRNA was assayed and calculated. The target genes of the miRNA were predicted, and the gene function was speculated by the enrichment analysis. Our research has revealed miRNAs like miR-671-5p, miR-29a-3p, and miR-700-3p may play vital roles in the interaction with key genes. More evidence about interaction between genes and miRNAs and the downstream signal pathways need to be explored. Mice in trial group were irradiated by UVA every other day for 4 months, and the irradiation dosage is 89.88 J/cm^2 in total.