Additional file 9 of An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis

Additional file 9: Data S4. In silico screening predictions of combinatorial treatments. (Microsoft Excel Worksheet). This file reports the results of a screening of combinatorial perturbations. More particularly, it reports all conditions that lead to a transition towards a healthy chondrocyte (SOX9+) when starting from a hypertrophic-like chondrocyte (Runx2+). The first sheet reports conditions leading to such transition 100% of the time, between 99 and 90% of the time for the next sheet and so on. The TFs sheet references all the transcription factors of the model that could be retrieved in the result and that are less convenient to target experimentally (to define exclusion criteria for the experimental validation). The ‘Summary’ sheet, reports a list of conditions that might be interesting to test. It excludes conditions involving TFs.