Cleaned dataset for PubChem AID 1347031: qHTS assay of progesterone receptor (PR) antagonists

This dataset is derived from PubChem BioAssay AID 1347031, titled "Progesterone receptor (PR) small molecule antagonists, qHTS assay: Summary". The original assay is part of the Tox21 program and evaluates inhibition of progesterone receptor (PR) signaling using a beta-lactamase reporter assay in HEK293 cells engineered with a PR-responsive reporter system. Original dataset statistics: - Tested compounds: 7,671 - Active (antagonists): 861 - Inactive: 5,723 Data preprocessing: - Removed duplicate entries based on compound identifiers. - Resolved conflicting labels by excluding compounds with inconsistent activity annotations. Final cleaned dataset: - Total compounds: 6,250 - Positive (antagonists): 760 - Negative (inactive): 5,490