Interaction of Tie2 and p85 of PI3K

The p85 subunit of phosphatidylinositol 3-kinase (PI3-kinase) associates with Tie2, most likely at phosphotyrosine 1102. This association leads on to the activation of Akt/PKB, a process linked to cell survival and antiapoptosis, and that may in part account for Tie2's role in vascular growth and maintenance.

磷脂酰肌醇3激酶（PI3-kinase）的p85亚基与Tie2蛋白相联，此联接最有可能发生在酪氨酸1102位磷酸化处。此联接进而导致Akt/PKB的激活，该过程与细胞存活和抗凋亡相关联，并在一定程度上解释了Tie2在血管生长与维持中的作用。