Gut microbiota in obese subjects undergoing bilio-intestinal bypass surgery. human gut metagenome

A growing body of evidence suggests that the gut microbiota is involved in the development of human obesity. Recently, bariatric surgery has emerged as a research model to explore the physiological mechanisms underlying both obesity and related diseases. The aim of the study was to investigate the impact of bilio-intestinal bypass (BIB) surgery on the gut microbiota of obese individuals. Fecal samples from eleven severely obese patients were collected before and six months after surgery, and analyzed using Illumina sequencing of 16S rRNA gene amplicons. The results highlight significant changes in the composition of gut microbiota that may have a role in improving obesity-related conditions following weight-loss surgery.