Electrochemical Amidation: Benzoyl Hydrazine/Carbazate and Amine as Coupling Partners

An electrochemical amidation of benzoyl hydrazine/carbazate
and
primary/secondary amine as coupling partners via concomitant cleavage
and formation of C(sp2)–N bonds has been achieved.
This methodology proceeds under metal-free and exogenous oxidant-free
conditions producing N2 and H2 as byproducts.
Mechanistic studies reveal the in situ generations
of both acyl and N-centered radicals from benzoyl
hydrazines and amines. The utility of this protocol is demonstrated
through a large-scale, and synthesis of bezafibrate, a hyperlipidemic
drug.