One-Pot Synthesis of Coumarin-3-carboxamides Containing a Triazole Ring via an Isocyanide-Based Six-Component Reaction

A facile,
efficient, and environmentally friendly approach has been developed
for the diversity oriented synthesis of trifunctional coumarin-amide-triazole
containing compounds. A wide variety of pharmacologically significant
and structurally interesting compounds were synthesized via a one-pot,
six-component, tandem Knoevenagel/Ugi/click reaction sequence from
readily available starting materials in ethanol at room temperature
in excellent overall yields. Substituents could be independently varied
at five different positions.