Crystal structure of human HDAC2 in complex with TNG260

Crystal structure of human HDAC2 in complex with TNG260 Descriptor: (R)-N-(4-amino-4'-fluoro-[1,1'-biphenyl]-3-yl)-4-(S-methylsulfonimidoyl)benzamide, 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... Authors: McMillan, B.J, Whittington, D.A. Deposit date: 2025-03-18 Release date: 2025-09-17 Last modified: 2025-10-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes STK11-Mutant Tumors to Anti-PD-1 Immunotherapy. Cancer Res., 85, 2025