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Effects of aging, primary osteoporosis, and cellular senescence on Human Mesenchymal Stem Cells

ChEBI2012-02-22 更新2026-07-21 收录

干细胞衰老

骨质疏松机制

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-35959 数据链接链接失效反馈

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资源简介：

Effects of aging, primary osteoporosis, and cellular senescence on Human Mesenchymal Stem Cells

应用场景：

创建时间：

2012-02-22

干细胞衰老

单细胞转录组学

Ageing of the hematopoietic stem cell (HSC) compartment is characterized by skewing towards the myeloid lineage and reduced stem cell function, the molecular basis of which is largely unknown. Using s

NIAID Data Ecosystem150

RNA-seq (SPIA-seq): Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential

干细胞衰老

转录因子重编程再生

The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming

NIAID Data Ecosystem60

Mitochondria-enriched hematopoietic stem cells exhibit elevated self-renewal capabilities, thriving within the context of aged bone marrow [bulk RNA-seq]

干细胞衰老

线粒体功能

The aging of hematopoietic stem cells (HSCs) significantly alters their characteristics. Mitochondria, essential for cellular metabolism, play a crucial role, and their dysfunction is a hallmark of ag

NIAID Data Ecosystem20

Additional file 6 of Biological activity reduction and mitochondrial and lysosomal dysfunction of mesenchymal stem cells aging in vitro

干细胞衰老

基因表达

Additional file 6. Table S3. List of transcripts of 120210 genes and their FPKM from transcriptome sequence in UMSC-P4 and UMSC-P9. Related to Figure 7A and 7B.

DataCite Commons2024-02-06 更新80

Transcription profiling of human mesenchymal stem cells to determine changes over the course of cellular aging

干细胞衰老

转录组学分析

Transcription profiling of human mesenchymal stem cells to determine changes over the course of cellular aging

ChEBI2008-10-20 更新30