Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292
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Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292 Descriptor: Serine/threonine-protein kinase B-raf, [(1,2,3,4,5,6-eta)-(1S,2R,3R,4R,5S,6S)-1-carboxycyclohexane-1,2,3,4,5,6-hexayl](chloro)(3-methyl-5,7-dioxo-6,7-dihydro-5H-pyrido[2,3-a]pyrrolo[3,4-c]carbazol-12-ide-kappa~2~N~1~,N~12~)ruthenium(1+) Authors: Xie, P, Streu, C, Qin, J, Pregman, H, Pagano, N, Meggers, E, Marmorstein, R. Deposit date: 2010-12-23 Release date: 2011-03-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3.2 Å) Cite: The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase. Biochemistry, 48, 2009
创建时间：
2010-12-23
