Single-cell Transcriptome Data of Mouse Thymus

The thymus plays a crucial role in the development and maintenance of the immune system by facilitating the maturation of T cells. Age-related thymic involution leads to a decline in immune function, contributing to increased susceptibility to infections and diseases in the elderly. However, the cellular mechanisms underlying thymic aging and involution are not fully understood. In this study, we performed single-cell RNA sequencing (scRNA-seq) on thymic tissues from young (4-week-old, BO611-007X0001, BO611-007X0002, BO611-007X0003) and aged (52-week-old, BO611-007X0004, BO611-007X0005, BO611-007X0006) C57BL/6J mice, with three biological replicates per age group. Our dataset provides a comprehensive single-cell atlas of the thymus across different ages, revealing changes in cell types and their abundances associated with aging. This resource offers valuable insights into the cellular heterogeneity of the thymus and lays the groundwork for further research into the mechanisms of immune aging and potential therapeutic interventions.