Cap analysis gene analysis (CAGE) of AML cells harbouring FLT3-ITD mutations
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE149964
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This SuperSeries is composed of the SubSeries listed below. The purpose of the experiment is to investigate transcriptome signatures of FLT3-ITD and TKD double mutations in AML cells (primary samples and Ba/F3 cell) and the underlying molecular mechanism of mutation-driven acquired resistance. We identify 310 upregulated and 22 downregulated promoters in FLT3-ITD/D835 mutant AML cells compared to cells with FLT3-ITD (FDR<0.05), and 1945 upregulated and 1470 downregulated promoters in FLT3-ITD/D835 mutant Ba/F3 cells compared to cells with FLT3-ITD. We examined differentially expressed promoters of FLT3-ITD AML cells expressing FLT3-ITD and AML cells expressing FLT3-ITD/D835
创建时间：
2023-05-10
