Ruthenium(II)-Catalyzed α‑Fluoroalkenylation of Oxime Ethers with gem-Difluorostyrenes via C–H Activation and C–F Cleavage

A novel route for ruthenium­(II)-catalyzed α-fluoroalkenylation of oxime ethers with gem-difluorostyrenes via C–H activation and C–F cleavage has been developed for the first time. Notably, the alkenyl units of products exhibit exclusive Z-configuration. This reaction features a broad substrate scope and good functional group tolerance. A plausible reaction mechanism is confirmed by an available cycloruthenated intermediate. Besides, the O-methyl oximyl-directing group can be readily removed to access the α-fluoroalkenylated acetophenones.