Translation Inhibitors Cause Abnormalities in Ribosome Profiling Experiments

Alliance of Genome Resources2026-08-01 收录

核糖体图谱实验

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https://www.yeastgenome.org/dataset/GSE59573 数据链接链接失效反馈

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Ribosome profiling and high-throughput sequencing provide unprecedented opportunities for the analysis of mRNA translation

Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor. Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor

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RNA-蛋白质互作

Rocaglamide A (RocA) typifies a class of protein synthesis inhibitors that selectively kill aneuploid tumor cells and repress translation of specific mRNAs. RocA targets eukaryotic initiation factor 4

NIAID Data Ecosystem50

D. melanogaster RNA helicase Me31B in complex with GIGYF

结构生物学

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D. melanogaster RNA helicase Me31B in complex with GIGYF Descriptor: ACETATE ION, ATP-dependent RNA helicase me31b, GIGYF family protein CG11148 Authors: Peter, D, Valkov, E. Deposit date: 2019-07-10

Protein Data Bank Japan2024-10-23 更新40

Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor

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抗癌药物靶点研究

NIAID Data Ecosystem20

Inhibition of protein translation is a major mechanism for the activity of the pan-PIM kinase inhibitor PIM447 in combination with Pomalidomide-dexamethasone in multiple myeloma

多发性骨髓瘤靶向治疗

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The overexpression of PIM kinases in hematologic malignancies, including multiple myeloma, make PIM inhibitors an attractive therapeutic strategy for these diseases. Recent preclinical data from our g

NIAID Data Ecosystem40

Engineered transfer RNAs for suppression of premature termination codons

遗传病基因治疗

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Premature termination codons (PTCs) are responsible for 10-15% of all inherited disease. PTC suppression during translation offers a promising approach to treat a variety of genetic disorders, yet sma

Mendeley Data30

Translation Inhibitors Cause Abnormalities in Ribosome Profiling Experiments

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