Gene expression profiles in rat lung following intratracheal instillation with single-wall carbon nanotubes

Gene expression profiling of the rat lung following intratracheal instillation with single-wall carbon nanotubes (SWCNTs) was employed to gain insights into these molecular events. We attempted to characterize time-dependent changes in the gene expression until 754 days after intratracheal instillation with SWCNTs suspensions at 0.2 mg (L-SWCNT) and 0.4 mg (H-SWCNT) injected dose per rat, and to identify the shift from the acute-phase to the chronic-phase phase on the basis of evaluation at the molecular level.本研究通过对气管内滴注单壁碳纳米管（single-wall carbon nanotubes, SWCNTs）后的大鼠肺开展基因表达谱分析，以深入探究这类分子事件。本研究旨在表征每只大鼠分别接受0.2 mg（低剂量单壁碳纳米管，L-SWCNT）与0.4 mg（高剂量单壁碳纳米管，H-SWCNT）的SWCNTs悬液注射后，直至滴注后754天的基因表达时间依赖性变化，并基于分子水平的评估，识别从急性期向慢性期的转变过程。