METH consumption induced the differential expression of miRNA in Rat model

Male rats received daily injections of saline or methamphetamine (10 mg/kg, at 12 h intervals) for 2 weeks and for 4 weeks. Changes in gene expression were assessed by miRNA-sequencing after 6 hours following the last injection. Methamphetamine induced changes in the whole transcriptome were significantly greater in the left ventricle of the hearts than that in the normal rat both in terms of the number of genes affected and the magnitude of the changes. Overall design: Gene expression profiling of the left ventricle tissue of rats following treatment with methamphetamine or saline.